Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins

@article{Chen2005CondensedMC,
  title={Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins},
  author={Danyang Chen and Miroslav Dundr and Chen Wang and Anthony Kar Lun Leung and Angus I. Lamond and Tom Misteli and Sui Huang},
  journal={The Journal of Cell Biology},
  year={2005},
  volume={168},
  pages={41 - 54}
}
During mitosis, chromosomes are highly condensed and transcription is silenced globally. One explanation for transcriptional repression is the reduced accessibility of transcription factors. To directly test this hypothesis and to investigate the dynamics of mitotic chromatin, we evaluate the exchange kinetics of several RNA polymerase I transcription factors and nucleosome components on mitotic chromatin in living cells. We demonstrate that these factors rapidly exchange on and off ribosomal… CONTINUE READING

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