Condensation of the chromatin at the membrane of an apoptotic nucleus is not associated with activation of an endonuclease.

  title={Condensation of the chromatin at the membrane of an apoptotic nucleus is not associated with activation of an endonuclease.},
  author={F A Oberhammer and Gerhard Fritsch and Matthias Schmied and Meredith Pavelka and Dieter Printz and Tony F Purchio and Hans Lassmann and Rolf Schulte-Hermann},
  journal={Journal of cell science},
  volume={104 ( Pt 2)},
A current hypothesis holds that chromatin fragmentation into oligonucleosomal patterns is an early event during apoptosis. In contrast, induction of apoptosis in cultured hepatocytes by TGF-beta 1 was not associated with DNA fragmentation into oligonucleosomes in hepatocyte monolayers and apoptotic fragments. For a more rigorous test of the hypothesis we performed a number of experiments. We compared nuclear changes resulting from TGF-beta 1 with those induced by Ca2+, a known activator of… CONTINUE READING


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