Concurrent use of methotrexate and celecoxib increases risk of silent liver fibrosis in rheumatoid arthritis patients with subclinical reduced kidney function

@article{Park2014ConcurrentUO,
  title={Concurrent use of methotrexate and celecoxib increases risk of silent liver fibrosis in rheumatoid arthritis patients with subclinical reduced kidney function},
  author={Jin Su Park and Min Chan Park and Yong-Beom Park and Soo-Kon Lee and Sang-Won Lee},
  journal={Clinical Rheumatology},
  year={2014},
  volume={33},
  pages={1415-1423}
}
We evaluated the effects of concurrent use of methotrexate and celecoxib on silent liver and kidney damages in rheumatoid arthritis (RA) patients. We enrolled 92 RA patients with normal laboratory results related to liver and kidney functions, who had received methotrexate and celecoxib concurrently over 6 months. Liver stiffness measurement (LSM) using transient elastography and ultrasonography were performed along with blood and urine tests. Estimated glomerular filtration rate (eGFR) was… CONTINUE READING

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