Concurrent use of ganciclovir and foscarnet to treat cytomegalovirus infection in AIDS patients.

@article{Dieterich1993ConcurrentUO,
  title={Concurrent use of ganciclovir and foscarnet to treat cytomegalovirus infection in AIDS patients.},
  author={Douglas T. Dieterich and Michael A. Poles and Edward A Lew and Pedro E M{\'e}ndez and Rob Murphy and A Addessi and Janet T Holbrook and Kathleen Mac Naughton and Dorothy N Friedberg},
  journal={The Journal of infectious diseases},
  year={1993},
  volume={167 5},
  pages={1184-8}
}
Ten patients with AIDS and progressive cytomegalovirus disease were treated with ganciclovir and foscarnet concurrently. The patients had received ganciclovir and foscarnet monotherapy a median of 330 days before receiving combination therapy for a median of 80 days. Nine of the 10 patients responded to the combination. No electrolyte abnormalities were noted during combination therapy, but rates of neutropenia (relative rate, combination vs. ganciclovir, 1.99; P = .229) and thrombocytopenia… CONTINUE READING