Concurrent unilateral chromatid damage and DNA strand breakage in response to 6-thioguanine treatment.

@article{Fairchild1986ConcurrentUC,
  title={Concurrent unilateral chromatid damage and DNA strand breakage in response to 6-thioguanine treatment.},
  author={Craig R. Fairchild and Jonathan Maybaum and Katherine A. Kennedy},
  journal={Biochemical pharmacology},
  year={1986},
  volume={35 20},
  pages={3533-41}
}
The delayed cytotoxicity of 6-thioguanine (TG) may relate to the arrest of cells in G2 upon completion of one cell cycle after drug exposure. In Chinese hamster ovary (CHO) cells, both the unilateral chromatid damage in G2 chromosomes, determined by induction of premature condensed chromosome condensation [Maybaum and Mandel, Cancer Res. 43, 3852 (1983)], and incorporation of TG into DNA resulting in DNA strand breakage [Christie et al., Cancer Res. 44, 3665 (1984)] were correlated with… CONTINUE READING

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Mentioned Connections BETA
ChromatidsAnatomic structure is physical part ofChromosomes
Prominent curving of G2 chromosomes with gapping and diffuse staining of one of the sister chromatids occurred .
Treatment of cells with 0.25 microM TG for 12 hr , and transfer to drug - free medium for 12 hr prior to making prematurely condensed chromosomes ( PCC ) , resulted in unilateral chromatid damage .
In Chinese hamster ovary ( CHO ) cells , both the unilateral chromatid damage in G2 chromosomes , determined by induction of premature condensed chromosome condensation [ Maybaum and Mandel , Cancer Res .
Prominent curving of G2 chromosomes with gapping and diffuse staining of one of the sister chromatids occurred .
Treatment of cells with 0.25 microM TG for 12 hr , and transfer to drug - free medium for 12 hr prior to making prematurely condensed chromosomes ( PCC ) , resulted in unilateral chromatid damage .
In Chinese hamster ovary ( CHO ) cells , both the unilateral chromatid damage in G2 chromosomes , determined by induction of premature condensed chromosome condensation [ Maybaum and Mandel , Cancer Res .
Prominent curving of G2 chromosomes with gapping and diffuse staining of one of the sister chromatids occurred .
Treatment of cells with 0.25 microM TG for 12 hr , and transfer to drug - free medium for 12 hr prior to making prematurely condensed chromosomes ( PCC ) , resulted in unilateral chromatid damage .
In Chinese hamster ovary ( CHO ) cells , both the unilateral chromatid damage in G2 chromosomes , determined by induction of premature condensed chromosome condensation [ Maybaum and Mandel , Cancer Res .
In Chinese hamster ovary ( CHO ) cells , both the unilateral chromatid damage in G2 chromosomes , determined by induction of premature condensed chromosome condensation [ Maybaum and Mandel , Cancer Res .
Treatment of cells with 0.25 microM TG for 12 hr , and transfer to drug - free medium for 12 hr prior to making prematurely condensed chromosomes ( PCC ) , resulted in unilateral chromatid damage .
In Chinese hamster ovary ( CHO ) cells , both the unilateral chromatid damage in G2 chromosomes , determined by induction of premature condensed chromosome condensation [ Maybaum and Mandel , Cancer Res .
Prominent curving of G2 chromosomes with gapping and diffuse staining of one of the sister chromatids occurred .
In Chinese hamster ovary ( CHO ) cells , both the unilateral chromatid damage in G2 chromosomes , determined by induction of premature condensed chromosome condensation [ Maybaum and Mandel , Cancer Res .
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