Concurrent treatment with renin-angiotensin system blockers and acetylsalicylic acid reduces nuclear factor kappaB activation and C-reactive protein expression in human carotid artery plaques.

@article{Sattler2005ConcurrentTW,
  title={Concurrent treatment with renin-angiotensin system blockers and acetylsalicylic acid reduces nuclear factor kappaB activation and C-reactive protein expression in human carotid artery plaques.},
  author={Katherine J E Sattler and Julie E Woodrum and Offer Galili and Monica L. Olson and Saquib Samee and Fredric B. Meyer and Xiang-yang Zhu and Lilach O Lerman and Amir Lerman},
  journal={Stroke},
  year={2005},
  volume={36 1},
  pages={
          14-20
        }
}
BACKGROUND AND PURPOSE The local renin-angiotensin system (RAS) and cyclooxygenase-2 contribute to the activation of nuclear factor kappaB (NFkappaB) and C-reactive protein (CRP). We hypothesized that the combination of RAS blockers (RASb) and ASA reduces NFkappaB and CRP within atherosclerotic plaques. METHODS Patients undergoing carotid endarterectomy were divided into groups according to treatment (RASb-acetylsalicylic acid [ASA], ASA, RASb, and control). The expression of NFkappaB, CRP… CONTINUE READING

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