Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?

@article{Kearn2005ConcurrentSO,
  title={Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?},
  author={Christopher S. Kearn and Katherine G. Blake-Palmer and E. L. F. Daniel and Ken Mackie and Michelle Glass},
  journal={Molecular pharmacology},
  year={2005},
  volume={67 5},
  pages={1697-704}
}
Dopamine and endogenous cannabinoids display complex interactions in the basal ganglia. One possible level of interaction is between CB1 cannabinoid and D2 dopamine receptors. Here, we demonstrate that a regulated association of CB1 and D2 receptors profoundly alters CB1 signaling. This provides the first evidence that CB1/D2 receptor complexes exist, are dynamic, and are agonist-regulated with highest complex levels detected when both receptors are stimulated with subsaturating concentrations… CONTINUE READING
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