Concurrent radiotherapy and tumor targeting with 111In-HMFG1-F(ab')2 in patients with MUC1-positive non-small cell lung cancer.


BACKGROUND Combining external radiotherapy (XRT) and radioimmunotargeting might enhance tumor radiation without affecting morbidity, due to different toxicity profiles. AIM To assess 111In-F(ab')2-HMFG1 biodistribution, the influence of "low-dose" lysine on F(ab')2 renal uptake and provide data forfurther concurrent XRT and RIT. PATIENTS AND METHODS… (More)