Concurrent nitroglycerin therapy impairs tissue-type plasminogen activator-induced thrombolysis in patients with acute myocardial infarction.

@article{Nicolini1994ConcurrentNT,
  title={Concurrent nitroglycerin therapy impairs tissue-type plasminogen activator-induced thrombolysis in patients with acute myocardial infarction.},
  author={Francesca A. Nicolini and Donatella Ferrini and Filippo Ottani and M. Galvani and Anna Maria Ronchi and Peter Behrens and Franco Rusticali and Jawahar Lal Mehta},
  journal={The American journal of cardiology},
  year={1994},
  volume={74 7},
  pages={662-6}
}
Nitroglycerin given with tissue-type plasminogen activator (t-PA) has been shown to decrease the thrombolytic effect of t-PA in animal models of coronary artery thrombosis. The present study was conducted to determine whether such an interaction between nitroglycerin and t-PA occurs in patients with acute myocardial infarction undergoing thrombolytic… CONTINUE READING