Concurrent mood and anxiety disorders are associated with pharmacoresistant seizures in patients with MTLE

  title={Concurrent mood and anxiety disorders are associated with pharmacoresistant seizures in patients with MTLE},
  author={Mateus Henrique Nogueira and Clarissa Lin Yasuda and Ana Carolina Coan and Andres M. Kanner and Fernando Cendes},
To investigate whether mood disorders (MD) and anxiety disorders (AD) are associated with seizure control in patients with mesial temporal lobe epilepsy (MTLE). We compared patients without any current psychiatric disorder, patients with current MD and/or AD, patients with subsyndromic depression episodes (SSDE) and anxiety episodes (SSAE), and patients with family psychiatric history. 

Depressive disorders in patients with pharmaco-resistant mesial temporal lobe epilepsy

Depressive disorders are common, underdiagnosed and undertreated in patients with refractory MTLE, and no significant difference was found between patients with and without depression and the presence of HA.

Epilepsy and anxiety.

  • M. TuftO. HenningK. Nakken
  • Psychology, Medicine
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
  • 2018
Up to one-quarter of people with epilepsy have mental health disorders in addition to seizures, and psychiatric symptoms can reduce quality of life more than epileptic seizures.

Psychiatric Comorbidities in People With Epilepsy.

All patients with epilepsy should be routinely screened for psychiatric disorder at the onset and at least once a year, and patients and their relatives should be informed of the risk of mental health problems and the implications.

Epilepsy and mood disorders

  • M. Mula
  • Psychology, Medicine
    The Comorbidities of Epilepsy
  • 2019

Neuropsychiatric Treatments for Epilepsy: Nonpharmacological Approaches.

An overview of non-pharmacological treatments currently available to patients with epilepsy (PWE) are provided-and their effect on mood and anxiety disorders as well as epilepsy is reviewed.

Major Depressive Disorder Associated With Reduced Cortical Thickness in Women With Temporal Lobe Epilepsy

The identification of areas with reduced CT and atrophy of the ipsilateral amygdala in women with MTLE and MDD suggest that the cortical thinning in the network of the paralimbic system is related to the co-occurrence and intensity of depressive symptoms in this group.

Worrying More about Anxiety in Patients with Epilepsy

Validated instruments such as the Generalized Anxiety Disorder, Hospital Anxiety and Depression Scale, the Patient Health Questionnaire-9, or Neurologic Disorders Depression Inventory for Epilepsy (NDDI-E) are important for neurologists to incorporate into their regular visits in order to formally screen their patients and uncover who is at higher risk of harm and who needs treatment, although there are likely systems reasons that this is generally not done.

Common psychiatric comorbidities in epilepsy: How big of a problem is it?




Depressive and anxiety disorders in epilepsy: Do they differ in their potential to worsen common antiepileptic drug–related adverse events?

Purpose:  To compare the effect of anxiety disorders, major depressive episodes (MDEs), and subsyndromic depressive episodes (SSDEs) on antiepileptic drug (AED)–related adverse events (AEs) in

Anxiety disorders, subsyndromic depressive episodes, and major depressive episodes: Do they differ on their impact on the quality of life of patients with epilepsy?

Aims of the study:  To compare the impact of anxiety disorders, major depressive episodes (MDEs), and subsyndromic depressive episodes (SSDEs) on the quality of life of patients with epilepsy (PWEs),

Prevalence of psychiatric disorders in patients with mesial temporal sclerosis

There was a high prevalence of PD in patients with refractory TLE associated to MTS, the most common were mood and psychotic disorders, and Psychosis was significantly associated to left side.

Topiramate and Psychiatric Adverse Events in Patients with Epilepsy

This study determined the prevalence of psychiatric adverse events (PAEs) in patients with epilepsy treated with topiramate and identified a patient profile at risk of developing PAEs.

Depression and Epilepsy: A New Perspective on Two Closely Related Disorders

  • A. Kanner
  • Psychology, Medicine
    Epilepsy currents
  • 2006
Patients with suicidal ideation, psychotic symptoms, or bipolar disorders should be referred immediately to the care of a psychiatrist, and Neurologists should be well trained to provide psychopharmacologic treatment for major depressive episodes, dysthymic disorders, and minor depression.

Lennox-Lombroso Lecture, 2013: Psychiatric Comorbidities through the Life of the Seizure Disorder: A Complex Relation with a Not So Complex Solution

  • A. Kanner
  • Psychology, Medicine
    Epilepsy currents
  • 2014
The clinical implications of understanding the course of psychiatric comorbidities relative to the onset of the seizure disorder to minimize their risk of recurrence and their interference in the management ofThe seizure disorder are highlighted.

Epilepsy, suicidality, and psychiatric disorders: A bidirectional association

A study was undertaken to determine whether psychiatric disorders associated with suicide are more common in incident epilepsy than in matched controls without epilepsy, before and after epilepsy

Psychiatric comorbidities and epilepsy: Is it the old story of the chicken and the egg?

  • A. Kanner
  • Psychology, Medicine
    Annals of neurology
  • 2012
Data from this study support the reported association between seizure occurrence and overdoses with antidepressant drugs in humans and suggest a protective effect against the occurrence of unprovoked seizures of selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reptake inhibitors in patients with primary major depressive episodes.