Concurrent modulation of anxiety and memory

@article{Wall2000ConcurrentMO,
  title={Concurrent modulation of anxiety and memory},
  author={Philip M. Wall and Claude Messier},
  journal={Behavioural Brain Research},
  year={2000},
  volume={109},
  pages={229-241}
}
We have previously shown that the ventromedial prefrontal cortex (vmPFC) is involved in spontaneous working memory and anxiety-related behaviour in CD-1 mice. Specifically, pretrial microinjection of the kappa(1) agonist, U-69,593, in the infralimbic (IL) area of the vmPFC produced a robust anxiolytic behavioural profile in the elevated plus-maze and enhanced spontaneous working memory in the Y-maze. In the present study we sought to determine whether these effects were specific to IL kappa… 

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  • Psychology, Medicine
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TLDR
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References

SHOWING 1-10 OF 131 REFERENCES
U-69,593 microinjection in the infralimbic cortex reduces anxiety and enhances spontaneous alternation memory in mice
TLDR
The present report investigated the contributions of the ventromedial prefrontal cortex to the control of spontaneous alternation/working memory and anxiety-related behaviour and concluded that kappa receptors may exert on neurochemical responsivity to anxiety-provoking environments in the IL area of the mPFC.
Modulation of anxiety-related behaviours following lesions of the prelimbic or infralimbic cortex in the rat
TLDR
It is concluded that both the prelimbic and infralimbic regions play a role in anxiety, and that this role may be subtly differentiated, and in particular, the infalimbic cortex may have a specific role in mediating the inhibition of behaviours associated with aversive outcomes.
The interplay of learning and anxiety in the elevated plus-maze
  • S. File
  • Medicine, Psychology
    Behavioural Brain Research
  • 1993
TLDR
It is suggested that during the first 5 min in the elevated plus-maze the rats are acquiring a fear of heights and it is this phobic anxiety state that is measured during the second 5-min trial and the nature of the anxiety generated by the maze is different on trials 1 and 2.
The Effects of Muscarinic Cholinergic Receptor Blockade in the Rat Anterior Cingulate and Prelimbic/Infralimbic Cortices on Spatial Working Memory
TLDR
It is suggested that muscarinic transmission in the prelimbic/infralimbic cortices, but not the anterior cingulate cortex, is important for spatial working memory.
Role of the Amygdala in the Coordination of Behavioral, Neuroendocrine, and Prefrontal Cortical Monoamine Responses to Psychological Stress in the Rat
TLDR
Evidence is provided of amygdalar control of stress-induced metabolic activation of the monoaminergic systems in the m-PFC, as well as amygdAlar integration of behavioral and neuroendocrine components of the rat stress response.
Neuroanatomical characterization of Fos induction in rat behavioral models of anxiety
TLDR
Select common brain regions were identified that express Fos-LI in empirical models of anxiety that provide a functional framework to explore neuroanatomical sites of action of psychotherapeutic drugs that influence behavioral responses in these tasks.
Effects of infusion of cholinergic drugs into the prefrontal cortex area on delayed matching to position performance in the rat
TLDR
Results suggest that cholinergic systems in the mPFC play a role in directing attention to task relevant behavior and indicate that scopolamine does not specifically affect working memory.
A Five Minute Experience in the Elevated Plus-Maze Alters the State of the Benzodiazepine Receptor in the Dorsal Raphe Nucleus
TLDR
Analysis of locomotor activity in both tests showed that the changed responsivity to midazolam could not be explained by habituation, because on none of the measures used was there any difference in motor activity scores between plus-maze-naive and experienced rats.
Spatial delayed alternation of rats in a T-maze: effects of neurotoxic lesions of the medial prefrontal cortex and of T-maze rotations
TLDR
Subjecting the well-trained sham-operated animals to a series of systematic trial-to-trial variations in the position of the maze in the experimental room severely impaired the performance of the SDA task, indicating that extra-maze information is required to solve this task.
[Behavioral and neurochemical study on the role of the brain cholecystokinin system in anxiety].
  • T. Izumi
  • Chemistry, Medicine
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science
  • 1998
TLDR
The results suggest that the brain CCKB receptors are involved in the regulation of anxiety, and that the anxiolytic effects of CCKB receptor antagonists are mediated by increasing dopamine activity in the medial prefrontal cortex.
...
1
2
3
4
5
...