Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders

  title={Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders},
  author={Tomoya Muto and Goro Sashida and Motohiko Oshima and George Russel Wendt and Makiko Mochizuki-Kashio and Yasunobu Nagata and Masashi Sanada and Satoru Miyagi and Atsunori Saraya and Asuka Kamio and Genta Nagae and Chiaki Nakaseko and Koutaro Yokote and Kazuya Shimoda and Haruhiko Koseki and Yutaka Suzuki and Sumio Sugano and Hiroyuki Aburatani and Seishi Ogawa and Atsushi Iwama},
  booktitle={The Journal of experimental medicine},
Polycomb group (PcG) proteins are essential regulators of hematopoietic stem cells. Recent extensive mutation analyses of the myeloid malignancies have revealed that inactivating somatic mutations in PcG genes such as EZH2 and ASXL1 occur frequently in patients with myelodysplastic disorders including myelodysplastic syndromes (MDSs) and MDS/myeloproliferative neoplasm (MPN) overlap disorders (MDS/MPN). In our patient cohort, EZH2 mutations were also found and often coincided with tet… CONTINUE READING
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