Concurrent interaction of DCs with CD4+ and CD8+ T cells improves secondary CTL expansion: It takes three to tango

@article{Hoyer2014ConcurrentIO,
  title={Concurrent interaction of DCs with CD4+ and CD8+ T cells improves secondary CTL expansion: It takes three to tango},
  author={Stefanie Hoyer and Sabrina Prommersberger and Isabell A Pfeiffer and Beatrice Schuler-Thurner and Gerold Schuler and Jan D{\"o}rrie and Niels Schaft},
  journal={European Journal of Immunology},
  year={2014},
  volume={44}
}
T‐cell help is essential for CTL‐memory formation. Nevertheless, it is unclear whether the continuous presence of CD4+ T‐helper (Th) cells is required during dendritic cell (DC)/CD8+ T‐cell encounters, or whether a DC will remember the helper signal after the Th cell has departed. This question is relevant for the design of therapeutic cancer vaccines. Therefore, we investigated how human DCs need to interact with CD4+ T cells to mediate efficient repetitive CTL expansion in vitro. We… 
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