Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis

@article{Lagresle1996ConcurrentEO,
  title={Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis},
  author={Chantal Lagresle and Paul Mondi{\`e}re and Chantal Bella and Peter Heinrich Krammer and Thierry Defrance},
  journal={The Journal of Experimental Medicine},
  year={1996},
  volume={183},
  pages={1377 - 1388}
}
Naive and memory B cells were isolated from human tonsils and examined for expression of APO-1/Fas and for their sensitivity to the APO-1-dependent apoptosis. APO-1 was found to be constitutively expressed on memory but not on naive B cells. The susceptibility of both cell types to the APO-1 apoptotic pathway was acquired upon CD40 triggering and was correlated with increased expression of the APO-1 receptor. Both naive and memory B cells were protected from the APO-1-mediated death signal… CONTINUE READING
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