Concurrent administration of D-penicillamine and zinc has no advantages over the use of either single agent on copper excretion in the rat.

Abstract

The present study was conducted to examine in rats whether the combined use of D-penicillamine (DPA) and a zinc salt, or the administration of a DPA/Zn complex could have some advantages over the use of either single agent on the excretion of copper. In a first experiment, three groups of adult male Sprague Dawley rats were given by gavage one of the… (More)

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