Concurrent Activation of Striatal Direct and Indirect Pathways During Action Initiation

@inproceedings{Cui2013ConcurrentAO,
  title={Concurrent Activation of Striatal Direct and Indirect Pathways During Action Initiation},
  author={Guohong Cui and Sang Beom Jun and Xin Jin and Michael D. Pham and Steven S. Vogel and David M. Lovinger and Rui M Costa},
  booktitle={Nature},
  year={2013}
}
The basal ganglia are subcortical nuclei that control voluntary actions, and they are affected by a number of debilitating neurological disorders. The prevailing model of basal ganglia function proposes that two orthogonal projection circuits originating from distinct populations of spiny projection neurons (SPNs) in the striatum—the so-called direct and indirect pathways—have opposing effects on movement: activity of direct-pathway SPNs is thought to facilitate movement, whereas activity of… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 34 references

A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2012

Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors.

Proceedings of the National Academy of Sciences of the United States of America • 2010

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