Concurrent Activation of Striatal Direct and Indirect Pathways During Action Initiation

  title={Concurrent Activation of Striatal Direct and Indirect Pathways During Action Initiation},
  author={Guohong Cui and Sang Beom Jun and Xin Jin and Michael D. Pham and Steven S. Vogel and David M. Lovinger and Rui M Costa},
The basal ganglia are subcortical nuclei that control voluntary actions, and they are affected by a number of debilitating neurological disorders. The prevailing model of basal ganglia function proposes that two orthogonal projection circuits originating from distinct populations of spiny projection neurons (SPNs) in the striatum—the so-called direct and indirect pathways—have opposing effects on movement: activity of direct-pathway SPNs is thought to facilitate movement, whereas activity of… CONTINUE READING
Highly Influential
This paper has highly influenced 24 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 219 extracted citations

The functional logic of corticostriatal connections

Brain Structure and Function • 2016
View 7 Excerpts
Highly Influenced

Optogenetic dissection of striatopallidal pathway in control of motor activity

Surpris, Maripierre, +4 authors PAYEN SURPRIS
View 5 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 34 references

A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2012

Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors.

Proceedings of the National Academy of Sciences of the United States of America • 2010

Similar Papers

Loading similar papers…