Concordant modulation of cysteinyl leukotriene receptor expression by IL-4 and IFN-gamma on peripheral immune cells.

@article{Early2007ConcordantMO,
  title={Concordant modulation of cysteinyl leukotriene receptor expression by IL-4 and IFN-gamma on peripheral immune cells.},
  author={S Brandon Early and Elizabeth Barekzi and Julie Negri and Kathleen Hise and Larry C Borish and John W. Steinke},
  journal={American journal of respiratory cell and molecular biology},
  year={2007},
  volume={36 6},
  pages={715-20}
}
Arachidonic acid can be metabolized to form a group of compounds known as the cysteinyl leukotrienes (CysLT) that bind to one of two receptors to mediate their actions. On circulating cells, expression of the leukotriene receptors is low, but in inflamed tissue the receptor number is dramatically increased. We hypothesized that the cytokine milieu present during inflammation can increase receptor expression on infiltrating immune cells. Various cell populations were purified from peripheral… CONTINUE READING

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Arachidonic acid can be metabolized to form a group of compounds known as the cysteinyl leukotrienes ( CysLT ) that bind to one of two receptors to mediate their actions .
Arachidonic acid can be metabolized to form a group of compounds known as the cysteinyl leukotrienes ( CysLT ) that bind to one of two receptors to mediate their actions .
Arachidonic acid can be metabolized to form a group of compounds known as the cysteinyl leukotrienes ( CysLT ) that bind to one of two receptors to mediate their actions .
Arachidonic acid can be metabolized to form a group of compounds known as the cysteinyl leukotrienes ( CysLT ) that bind to one of two receptors to mediate their actions .
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