Concordant DNA methylation in synchronous colorectal carcinomas.

Abstract

Epigenetic changes have been proposed as mediators of the field defect in colorectal carcinogenesis, which has implications for risk assessment and cancer prevention. As a test of this hypothesis, we evaluated the methylation status of eight genes (MINT1, 2, 31, MLH1, p16, p14, MGMT, and ESR1), as well as BRAF and KRAS mutations, in 57 multiple colorectal… (More)
DOI: 10.1158/1940-6207.CAPR-09-0054

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