Concordance of the toxicity of pharmaceuticals in humans and in animals.

@article{Olson2000ConcordanceOT,
  title={Concordance of the toxicity of pharmaceuticals in humans and in animals.},
  author={H. Olson and G. Betton and D. Robinson and K. Thomas and A. Monro and G. Kolaja and P. Lilly and J. Sanders and G. Sipes and W. Bracken and M. Dorato and K. Van Deun and P. Smith and B. Berger and A. Heller},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2000},
  volume={32 1},
  pages={
          56-67
        }
}
This report summarizes the results of a multinational pharmaceutical company survey and the outcome of an International Life Sciences Institute (ILSI) Workshop (April 1999), which served to better understand concordance of the toxicity of pharmaceuticals observed in humans with that observed in experimental animals. The Workshop included representatives from academia, the multinational pharmaceutical industry, and international regulatory scientists. The main aim of this project was to examine… Expand
1,473 Citations
The value of acute toxicity testing of pharmaceuticals for estimation of human response.
  • 6
A big data approach to the concordance of the toxicity of pharmaceuticals in animals and humans
  • 47
Justification for species selection for pharmaceutical toxicity studies
  • PDF
Integration of safety pharmacology endpoints into toxicology studies
  • J. Luft, G. Bode
  • Biology, Medicine
  • Fundamental & clinical pharmacology
  • 2002
  • 39
Reviewing the Utility of Two Species in General Toxicology Related to Drug Development
  • 11
Perspectives on non-clinical safety evaluation of drug metabolites through the JSOT workshop.
  • 5
The Journal of Toxicological Sciences
  • Highly Influenced
The Scientific Value of Non-Clinical Animal Studies in Drug Development
  • 2
  • Highly Influenced
  • PDF
Toxicity Testing in the 21st Century Beyond Environmental Chemicals
  • 65
  • PDF
Principles of Safety Pharmacology
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 37 REFERENCES
The concept of multispecies testing in industrial toxicology.
  • G. Zbinden
  • Biology, Medicine
  • Regulatory toxicology and pharmacology : RTP
  • 1993
  • 38
Predictive value of animal studies in toxicology.
  • G. Zbinden
  • Medicine
  • Regulatory toxicology and pharmacology : RTP
  • 1991
  • 70
Animal toxicology for early clinical trials with anticancer agents.
  • 66
Toxic effects of chemicals: difficulties in extrapolating data from animals to man.
  • S. Garattini
  • Biology, Medicine
  • Critical reviews in toxicology
  • 1985
  • 48
The duration of toxicity studies required to support repeated dosing in clinical investigation — a toxicologist’s opinion
  • 21
  • Highly Influential
The role of pharmacological profiling in safety assessment.
  • P. D. Williams
  • Medicine
  • Regulatory toxicology and pharmacology : RTP
  • 1990
  • 33
Drug Safety Tests and Subsequent Clinical Experience
  • A. Fletcher
  • Medicine
  • Journal of the Royal Society of Medicine
  • 1978
  • 77
Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985).
  • 427
...
1
2
3
4
...