Concordance of gene expression in human protein complexes reveals tissue specificity and pathology

@inproceedings{Brnigen2013ConcordanceOG,
  title={Concordance of gene expression in human protein complexes reveals tissue specificity and pathology},
  author={Daniela B{\"o}rnigen and Tune H. Pers and Lieven Thorrez and Curtis Huttenhower and Yves Moreau and S\oren Brunak},
  booktitle={Nucleic acids research},
  year={2013}
}
Disease-causing variants in human genes usually lead to phenotypes specific to only a few tissues. Here, we present a method for predicting tissue specificity based on quantitative deregulation of protein complexes. The underlying assumption is that the degree of coordinated expression among proteins in a complex within a given tissue may pinpoint tissues that will be affected by a mutation in the complex and coordinated expression may reveal the complex to be active in the tissue. We… CONTINUE READING
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