Concordance of clinical and molecular breast cancer subtyping in the context of preoperative chemotherapy response

@article{Ronde2009ConcordanceOC,
  title={Concordance of clinical and molecular breast cancer subtyping in the context of preoperative chemotherapy response},
  author={Jorma J. de Ronde and Juliane Hannemann and Hans Halfwerk and Lennart Mulder and Marieke Evelien Straver and Marie-Jeanne Vrancken Peeters and J. A. M. Wesseling and Marc J. van de Vijver and Lodewyk Frederik Ary Wessels and Sjoerd Rodenhuis},
  journal={Breast Cancer Research and Treatment},
  year={2009},
  volume={119},
  pages={119-126}
}
ER, PR and HER2 status in breast cancer are important markers for the selection of drug therapy. By immunohistochemistry (IHC), three major breast cancer subtypes can be distinguished: Triple negative (TNIHC), HER2+IHC and LuminalIHC (ER+IHC/HER2−IHC). By using the intrinsic gene set defined by Hu et al. five molecular subtypes (BasalmRNA, HER2+mRNA, Luminal AmRNA, Luminal BmRNA and Normal-likemRNA) can be defined. We studied the concordance between analogous subtypes and their prediction of… CONTINUE READING
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