Concordance of carcinogenic response between rodent species: potency dependence and potential underestimation.

@article{Piegorsch1992ConcordanceOC,
  title={Concordance of carcinogenic response between rodent species: potency dependence and potential underestimation.},
  author={Walter W. Piegorsch and Gregory J. Carr and Christopher J. Portier and David G Hoel},
  journal={Risk analysis : an official publication of the Society for Risk Analysis},
  year={1992},
  volume={12 1},
  pages={115-21}
}
The use of average qualitative concordance between two bioassay endpoints is considered, with emphasis directed at agreement between rats and mice from results of long-term carcinogenicity studies. It is noted that concordance varies as a function of the underlying potency or toxicity of the chemicals over which the averaging is performed. Thus, the averaging process dilutes large observed concordances from potent chemicals, and possibly inflates lower observed concordances from weakly active… CONTINUE READING

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