Concordance between parental origin of chromosome 13q loss and chromosome 6p duplication in sporadic retinoblastoma.

Abstract

Two hypotheses are capable of explaining nonrandom loss of one parent's alleles at tumor suppressor loci in sporadic cases of several pediatric cancers, including retinoblastoma--namely, preferential germ-line mutation or chromosome imprinting. We have examined 74 cases of sporadic retinoblastoma for tumors in which at least two genetic events--loss of… (More)

Topics

Cite this paper

@article{Naumova1994ConcordanceBP, title={Concordance between parental origin of chromosome 13q loss and chromosome 6p duplication in sporadic retinoblastoma.}, author={Anna V. Naumova and Malene Hansen and Laura E. Strong and P. A. Jones and Doris Hadjistilianou and Diego Mastrangelo and S Griegel and Manfred F. Rajewsky and J. Shields and L. Donoso}, journal={American journal of human genetics}, year={1994}, volume={54 2}, pages={274-81} }