Concordance between in vitro and in vivo dosimetry in the proinflammatory effects of low-toxicity, low-solubility particles: the key role of the proximal alveolar region.

@article{Donaldson2008ConcordanceBI,
  title={Concordance between in vitro and in vivo dosimetry in the proinflammatory effects of low-toxicity, low-solubility particles: the key role of the proximal alveolar region.},
  author={K. Donaldson and P. Borm and G. Oberdorster and K. Pinkerton and V. Stone and C. Tran},
  journal={Inhalation toxicology},
  year={2008},
  volume={20 1},
  pages={
          53-62
        }
}
We previously demonstrated the importance of the surface area burden as the key dose metric in the elicitation of inflammation in rat lungs by low-solubility, low-toxicity particles (LSLTP). We have now explored the dosimetry of LSLTP in vitro using epithelial cell interleukin (IL)-8 gene expression as a surrogate for potential of particles to cause inflammation. The proximal alveolar region (PAR) of the lung has been identified as a key site for the retention of respirable particles, as it… Expand
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