Concordance between in vitro and in vivo dosimetry in the proinflammatory effects of low-toxicity, low-solubility particles: the key role of the proximal alveolar region.

Abstract

We previously demonstrated the importance of the surface area burden as the key dose metric in the elicitation of inflammation in rat lungs by low-solubility, low-toxicity particles (LSLTP). We have now explored the dosimetry of LSLTP in vitro using epithelial cell interleukin (IL)-8 gene expression as a surrogate for potential of particles to cause… (More)
DOI: 10.1080/08958370701758742

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@article{Donaldson2008ConcordanceBI, title={Concordance between in vitro and in vivo dosimetry in the proinflammatory effects of low-toxicity, low-solubility particles: the key role of the proximal alveolar region.}, author={Ken Donaldson and Paul Borm and Gunter Oberdorster and Kent E Pinkerton and Vicki Stone and C Lang Tran}, journal={Inhalation toxicology}, year={2008}, volume={20 1}, pages={53-62} }