Concomitant use of clopidogrel and proton pump inhibitors: impact on platelet function and clinical outcome- a systematic review

@article{Focks2012ConcomitantUO,
  title={Concomitant use of clopidogrel and proton pump inhibitors: impact on platelet function and clinical outcome- a systematic review},
  author={J. J. Focks and M. Brouwer and M. V. van Oijen and {\'A}. Lanas and Deepak L. Bhatt and F. Verheugt},
  journal={Heart},
  year={2012},
  volume={99},
  pages={520 - 527}
}
Background Clopidogrel as an adjunct to aspirin has improved outcomes after acute coronary syndromes, but laboratory studies suggest a reduced antiplatelet effect when proton pump inhibitors (PPIs) are co-administered. Despite corroborating data from retrospective studies, new clinical data fuel the controversy on this issue. Purpose Systematic review of the impact of the addition of PPIs to clopidogrel on platelet function and cardiovascular outcome. Data sources PubMed, Web-of-Science… Expand
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