Concomitant presence of mutations in mitochondrial genome and p53 in cancer development - a study in north Indian sporadic breast and esophageal cancer patients.

@article{Gochhait2008ConcomitantPO,
  title={Concomitant presence of mutations in mitochondrial genome and p53 in cancer development - a study in north Indian sporadic breast and esophageal cancer patients.},
  author={Sailesh Gochhait and Audesh Bhatt and Swarkar Sharma and Yoginder Pal Singh and Pawan Gupta and R. N. K. Bamezai},
  journal={International journal of cancer},
  year={2008},
  volume={123 11},
  pages={2580-6}
}
Mitochondrial DNA alterations in recent years have been suggested as modifier events, providing a possible proliferative advantage to the tumor cells. In order to provide further insight into the process of tumorigenesis, a study of whole mitochondria genome was conducted in 134 tissue samples obtained from 2 unrelated cancers (tumor and adjacent normal tissues from 36 breast cancer and 31 esophageal squamous cell carcinoma (ESCC) patients) with known p53 somatic mutation background. Fifteen of… CONTINUE READING

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