Concomitant mobilization of plasma cells and hematopoietic progenitors into peripheral blood of multiple myeloma patients: positive selection and transplantation of enriched CD34+ cells to remove circulating tumor cells.

@article{Lemoli1996ConcomitantMO,
  title={Concomitant mobilization of plasma cells and hematopoietic progenitors into peripheral blood of multiple myeloma patients: positive selection and transplantation of enriched CD34+ cells to remove circulating tumor cells.},
  author={Roberto Massimo Lemoli and Alessandra Fortuna and Maria Rosa Motta and Simonetta Rizzi and Valeria Giudice and Anna Nannetti and Giovanni Martinelli and Michele Cavo and Marilina Amabile and Serena Mangianti and M. Fogli and R. N. Conte and Sante Tura},
  journal={Blood},
  year={1996},
  volume={87 4},
  pages={1625-34}
}
One advantage of the use of peripheral blood stem cells (PBSCs) over autologous bone marrow would be a reduced risk of tumor cell contamination. However, the level of neoplastic cells in the PB of multiple myeloma (MM) patients after mobilization protocols is poorly investigated. In this study, we evaluated PB samples from 27 pretreated MM patients after the administration of high dose cyclophosphamide (7 g/m2 or 4 g/m2) and granulocyte-colony stimulating factor for the detection of myeloma… CONTINUE READING
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