Concomitant granule cell neuronopathy in patients with natalizumab-associated PML

@inproceedings{Wijburg2015ConcomitantGC,
  title={Concomitant granule cell neuronopathy in patients with natalizumab-associated PML},
  author={Martijn T. Wijburg and Dorine A M Siepman and Jeroen J. J. van Eijk and Joep Killestein and Mike P. Wattjes},
  booktitle={Journal of Neurology},
  year={2015}
}
Granule cell neuronopathy (GCN) is a rare JC virus infection of the cerebellar granule cell neurons in immunocompromised patients. On brain imaging, GCN is characterized by cerebellar atrophy which can be accompanied by infratentorial white matter lesions. The objective of this study is to investigate the prevalence of MRI findings suggestive of GCN in a large natalizumab-associated progressive multifocal leukoencephalopathy (PML) cohort. MRI scans from before, at the time of, and during follow… CONTINUE READING
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