Concomitant emergence of the antisense protein gene of HIV-1 and of the pandemic.

  title={Concomitant emergence of the antisense protein gene of HIV-1 and of the pandemic.},
  author={{\'E}lodie Cassan and Anne-Muriel Arigon-Chifolleau and J E Mesnard and Antoine Gross and Olivier Gascuel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={113 41},
Recent experiments provide sound arguments in favor of the in vivo expression of the AntiSense Protein (ASP) of HIV-1. This putative protein is encoded on the antisense strand of the provirus genome and entirely overlapped by the env gene with reading frame -2. The existence of ASP was suggested in 1988, but is still controversial, and its function has yet to be determined. We used a large dataset of ∼23,000 HIV-1 and SIV sequences to study the origin, evolution, and conservation of the asp… CONTINUE READING
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