Concomitant characterization of behavioral and striatal neurotransmitter response to amphetamine using in vivo microdialysis.

@article{Kuczenski1989ConcomitantCO,
  title={Concomitant characterization of behavioral and striatal neurotransmitter response to amphetamine using in vivo microdialysis.},
  author={Ronald Kuczenski and D. S. Segal},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1989},
  volume={9 6},
  pages={2051-65}
}
The temporal and dose-related behavioral and striatal monoamine response to amphetamine (AMPH) was examined using in vivo microdialysis in freely moving rats. Extracellular dopamine (DA), serotonin (5-HT), and their metabolites were monitored concomitant with detailed characterization of the locomotor and stereotypy profiles. Consistent with previous results, AMPH (0.5-5.0 mg/kg) induced a rapid dose-dependent increase in DA concentration and decrease in the concentrations of the DA metabolites… CONTINUE READING
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