Concomitant carcinoma in situ is a feature of aggressive disease in patients with organ-confined TCC at radical cystectomy.

@article{Shariat2007ConcomitantCI,
  title={Concomitant carcinoma in situ is a feature of aggressive disease in patients with organ-confined TCC at radical cystectomy.},
  author={Shahrokh F Shariat and Ganesh S. Palapattu and Pierre I. Karakiewicz and Craig Rogers and Amnon Vazina and Patrick Jan Bastian and Mark P. Schoenberg and Seth P. Lerner and Arthur I. Sagalowsky and Yair Lotan},
  journal={European urology},
  year={2007},
  volume={51 1},
  pages={152-60}
}
OBJECTIVES Carcinoma in situ (CIS) is a nonpapillary, high-grade, potentially aggressive, and unpredictable manifestation of transitional cell carcinoma (TCC) of the bladder. The aim of this study was to assess whether presence of concomitant CIS has a detrimental effect on cancer control after radical cystectomy. METHODS The records of 812 consecutive patients who underwent radical cystectomy and pelvic lymphadenectomy for bladder TCC at three US academic centres were reviewed. Ninety-nine… CONTINUE READING
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