Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation

@article{Carminati2016ConcomitantBO,
  title={Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation},
  author={Manuel Carminati and Sara Gallini and Laura Pirovano and Andrea Alfieri and Sara Bisi and Marina Mapelli},
  journal={Nature Structural &Molecular Biology},
  year={2016},
  volume={23},
  pages={155-163}
}
Polarized epithelia form by oriented cell divisions in which the mitotic spindle aligns parallel to the epithelial plane. To orient the mitotic spindle, cortical cues trigger the recruitment of NuMA–dynein–based motors, which pull on astral microtubules via the protein LGN. We demonstrate that the junctional protein Afadin is required for spindle orientation and correct epithelial morphogenesis of Caco-2 cysts. Molecularly, Afadin binds directly and concomitantly to F-actin and to LGN. We… CONTINUE READING
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