Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB(1) cannabinoid receptor agonists on tyrosine hydroxylase expression.

@article{Bosier2009ConcomitantAO,
  title={Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB(1) cannabinoid receptor agonists on tyrosine hydroxylase expression.},
  author={Barbara Bosier and Emmanuel Hermans and Didier Lambert},
  journal={Biochemical pharmacology},
  year={2009},
  volume={77 2},
  pages={216-27}
}
The CB(1) cannabinoid receptor shows complex interactions with intracellular signalling partners, and responses to cannabinoid ligands are likely to be influenced by concomitant inputs modifying the overall tone of signalling cascades. This appears even more relevant as we previously evidenced opposite regulations of tyrosine hydroxylase (TH) expression by the two common cannabinoid agonists HU 210 and CP 55,940. Therefore, we studied the consequences of manipulating adenylyl cyclase activity… CONTINUE READING

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Biochemical Society symposium • 1993
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Highly Influenced

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