Concomitant DFMO and sulindac chemoprevention of colorectal adenomas: a major clinical advance

@article{Sporn2008ConcomitantDA,
  title={Concomitant DFMO and sulindac chemoprevention of colorectal adenomas: a major clinical advance},
  author={Michael B. Sporn and Waun Ki Hong},
  journal={Nature Clinical Practice Oncology},
  year={2008},
  volume={5},
  pages={628-629}
}
In a randomized, placebo-controlled, double-blind clinical trial by Meyskens et al. the combination of difluoromethylornithine and sulindac has been shown to be strikingly effective for prevention of sporadic colorectal adenomas. This concomitant use of two drugs to suppress the progression of preneoplastic lesions represents the first major clinical success of the application of the principle of 'combination chemoprevention'. Neither drug alone has previously had clinical utility at the low… CONTINUE READING
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