Conclusions not supported by methods and results

@article{Giacovelli2010ConclusionsNS,
  title={Conclusions not supported by methods and results},
  author={Giampaolo Giacovelli and Lucio Claudio Rovati},
  journal={BMJ : British Medical Journal},
  year={2010},
  volume={341}
}
Wandel and colleagues produced another meta-analysis of glucosamine in osteoarthritis without new evidence when more comprehensive ones showed that the quality controlled product of glucosamine sulphate for prescription is effective.1 2 3 4 Their statistical methods are so complex that many are mystified by whether the conclusions make sense.5 Indeed, we verified that a conventional approach gives identical results to their network meta-analysis … 
View on BMJ
ncbi.nlm.nih.gov
11 Citations
Background Citations
1

11 Citations

Citation Type

Citation Type

Interpretation of Metaanalyses: Pitfalls Should Be More Widely Recognized
On the basis of metaanalysis of randomized studies assessing the symptoms and radiological progression of patients with osteoarthritis (OA), investigators have concluded that health authorities and…
NSAID-sparing effect of glucosamine hydrochloride in patients with knee osteoarthritis: an analysis of data from a French database
TLDR
This large ‘real world’ analysis demonstrated a significant NSAID-sparing effect of glucosamine in patients with knee OA, and was significantly lower in Structoflex®-treated patients compared with control group patients.
Glucosamine for Osteoarthritis: Biological Effects, Clinical Efficacy, and Safety on Glucose Metabolism
TLDR
Evidence supporting diabetogenesis by glucosamine remains scarce in humans, and to date, this association should be considered only a theoretical possibility.
Sulfato de glucosamina y condroitín sulfato, fármacos para el tratamiento de la artrosis, acusados de no presentar eficacia clínica. ¿Culpables?
The glucosamine controversy; a pharmacokinetic issue.
  • A. Aghazadeh-Habashi, F. Jamali
  • Biology
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2011
TLDR
This work rule out a difference in bioequivalence between GlcN salts and that of chemically equivalent doses and suggest additional factors; i.e., inconsistency in the chemical potency of some products used, under-dosing of patients as well as variable and erratic bioavailability indices for the lack of Glcn efficacy observed in some studies.
COST-EFFECTIVENESS OF GLUCOSAMINE, CHONDROITIN SULFATE, THEIR COMBINATION, CELECOXIB, NON-SELECTIVE NON- STEROIDAL ANTI-INFLAMMATORY DRUGS, AND PLACEBO IN TREATING KNEE OSTEOARTHRITIS
TLDR
The costeffectiveness of conventional medicines such as non-steroidal anti-inflammatory drugs (NSAIDs) and celecoxib and complementary and alternative medicines (CAM) therapies to treat KOA is examined from the US health care payers’ and patients’ perspectives and from 24week, 2-year, and 10-year time-horizons.
Analysis of the Health and Budgetary Impact of Chondroitin Sulfate Prescription in the Treatment of Knee Osteoarthritis Compared to NSAIDs and COXIBs
TLDR
CS treatment is expected to prevent thousands of AEs over the next 3 years, some of which may be life-threatening for patients, while generating considerable savings for the NHS.
Tratamiento del paciente con artrosis
Complementary and alternative treatments in sports medicine.
15 – The Role of Chondroprotectants, Nutraceuticals, and Nutrition in Rehabilitation
...
...

References

SHOWING 1-5 OF 5 REFERENCES
Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis
TLDR
Compared with placebo, glucosamine, chondroitin, and their combination do not reduce joint pain or have an impact on narrowing of joint space and health authorities and health insurers should not cover the costs.
The efficacy of glucosamine sulfate in osteoarthritis: financial and nonfinancial conflict of interest.
TLDR
Two aspects of this issue deserve attention: the actual role of industry bias in clinical research, and an understanding of why the findings of the meta-analysis by Vlad et al are of concern.
Glucosamine therapy for treating osteoarthritis.
TLDR
The results are not uniformly positive, and the reasons for this remain unexplained, but glucosamine was superior to placebo in the treatment of pain and functional impairment resulting from symptomatic OA.
OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009.
Safety of drug-eluting stents: demystifying network meta-analysis