Concise synthesis of the isothiourea organocatalysts homobenzotetramisole and derivatives.

Abstract

A concise approach to the synthesis of homobenzotetramisole and derivatives is described. Our strategy features a one-pot acylation-cyclization of 2-aminobenzothiazole with α,β-unsaturated acid chlorides to afford annulated pyrimidones. Subsequent Grignard addition followed by acid-promoted dehydration and reduction provides good overall yields of the title… (More)
DOI: 10.1021/jo400603n

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