Concise synthesis of the antidepressive drug candidate GSK1360707 by a highly enantioselective gold-catalyzed enyne cycloisomerization reaction.

@article{Teller2011ConciseSO,
  title={Concise synthesis of the antidepressive drug candidate GSK1360707 by a highly enantioselective gold-catalyzed enyne cycloisomerization reaction.},
  author={Henrik Teller and Alois F{\"u}rstner},
  journal={Chemistry},
  year={2011},
  volume={17 28},
  pages={
          7764-7
        }
}
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The triple reuptake inhibitor GSK1360707F was synthesized via an efficient and scalable route that features an enyne cycloisomerization reaction catalyzed by either Pt(II) or Au(I). Key aspects of…
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Development of a New Synthesis for the Large-Scale Preparation of Triple Reuptake Inhibitor (−)-GSK1360707
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The recognition of the optical activity of organic compounds, followed by the detailed analysis of optical isomerism,1 laid the foundation for the development of asymmetric syntheses, a group of…
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