Concise review: genetic dissection of hypoxia signaling pathways in normal and leukemic stem cells.

@article{Gezer2014ConciseRG,
  title={Concise review: genetic dissection of hypoxia signaling pathways in normal and leukemic stem cells.},
  author={Deniz Gezer and Milica Vukovic and Tomoyoshi Soga and Patrick J. Pollard and Kamil R Kranc},
  journal={Stem cells},
  year={2014},
  volume={32 6},
  pages={1390-7}
}
Adult hematopoiesis depends on rare multipotent hematopoietic stem cells (HSCs) that self-renew and give rise to progenitor cells, which differentiate to all blood lineages. The strict regulation of the fine balance between self-renewal and differentiation is essential for normal hematopoiesis and suppression of leukemia development. HSCs and progenitor cells are commonly assumed to reside within the hypoxic BM microenvironment, however, there is no direct evidence supporting this notion… CONTINUE READING
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