Concise review: Pluripotency and the transcriptional inactivation of the female Mammalian X chromosome.

@article{Minkovsky2012ConciseRP,
  title={Concise review: Pluripotency and the transcriptional inactivation of the female Mammalian X chromosome.},
  author={Alissa Minkovsky and Sanjeet G. Patel and Kathrin Plath},
  journal={Stem cells},
  year={2012},
  volume={30 1},
  pages={48-54}
}
X chromosome inactivation (XCI) is a striking example of developmentally regulated, wide-range heterochromatin formation that is initiated during early embryonic development. XCI is a mechanism of dosage compensation unique to placental mammals whereby one X chromosome in every diploid cell of the female organism is transcriptionally silenced to equalize X-linked gene levels to XY males. In the embryo, XCI is random with respect to whether the maternal or paternal X chromosome is inactivated… CONTINUE READING

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