Concise enantioselective synthesis of cephalosporolide B, (4R)-4-OMe-cephalosporolide C, and (4S)-4-OMe-cephalosporolide C.

@article{Ma2013ConciseES,
  title={Concise enantioselective synthesis of cephalosporolide B, (4R)-4-OMe-cephalosporolide C, and (4S)-4-OMe-cephalosporolide C.},
  author={B. Ma and Zhuliang Zhong and H. Hu and H. Li and C. Zhao and X. Xie and X. She},
  journal={Chemistry, an Asian journal},
  year={2013},
  volume={8 7},
  pages={
          1391-4
        }
}
  • B. Ma, Zhuliang Zhong, +4 authors X. She
  • Published 2013
  • Chemistry, Medicine
  • Chemistry, an Asian journal
  • Ring around the rosie: The effective enantioselective synthesis of the antimalarial nonenolide title compounds was achieved in a convergent strategy. Oxy-Michael addition reaction was used to introduce the chiral methoxy group at C-4, and ring-closing metathesis (RCM) reaction (53 % yield) facilitated the key construction of the 10-membered ring. 
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