Concise drug review: pazopanib and axitinib.

  title={Concise drug review: pazopanib and axitinib.},
  author={Robin M. J. M. van Geel and Jos H. Beijnen and Jan H. M. Schellens},
  journal={The oncologist},
  volume={17 8},
Pazopanib and axitinib are both U.S. Food and Drug Administration approved ATP-competitive inhibitors of the vascular endothelial growth factor receptor. Pazopanib and axitinib have been shown to be effective and tolerable treatment options for patients with metastatic renal cell cancer and therefore have enlarged the armamentarium for this disease. This concise drug review discusses the clinical benefits, clinical use, mechanism of action, bioanalysis, pharmacokinetics, pharmacogenetics… CONTINUE READING
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