Concise asymmetric synthesis of (-)-sparteine.


A six-step asymmetric synthesis of natural (-)-sparteine from ethyl 7-iodohept-2-enoate is reported, involving a connective Michael addition of an amino ester-derived enolate to an alpha,beta-unsaturated amino ester.

Cite this paper

@article{Hermet2004ConciseAS, title={Concise asymmetric synthesis of (-)-sparteine.}, author={Jean-Paul R Hermet and Matthew J. McGrath and Peter R. O'Brien and David W. Porter and John P Gilday}, journal={Chemical communications}, year={2004}, volume={16}, pages={1830-1} }