Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing

@article{Chamberlain2007ConciseRM,
  title={Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing},
  author={Giselle Chamberlain and James M. Fox and Brian A. Ashton and Jim F Middleton},
  journal={STEM CELLS},
  year={2007},
  volume={25}
}
MSCs are nonhematopoietic stromal cells that are capable of differentiating into, and contribute to the regeneration of, mesenchymal tissues such as bone, cartilage, muscle, ligament, tendon, and adipose. MSCs are rare in bone marrow, representing ∼1 in 10,000 nucleated cells. Although not immortal, they have the ability to expand manyfold in culture while retaining their growth and multilineage potential. MSCs are identified by the expression of many molecules including CD105 (SH2) and CD73… 
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The current clinical and nonclinical data for the use of MSCs in tissue repair and potential therapeutic role in various diseases are summarized.
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A comprehensive review on MSCs populations of the WJ and how these cell populations may be used for future applications in CNS regenerative medicine is made by critically reviewing the work that has been performed so far.
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