Concise Review: Genomic Instability in Human Stem Cells: Current Status and Future Challenges

@article{Oliveira2014ConciseRG,
  title={Concise Review: Genomic Instability in Human Stem Cells: Current Status and Future Challenges},
  author={P. Oliveira and Cl{\'a}udia Lobato Silva and J. Cabral},
  journal={STEM CELLS},
  year={2014},
  volume={32}
}
Genomic instability is recognized as one of the most important hurdles in the expanding field of stem cell‐based therapies. In the recent years, an accumulating body of evidence has shown that human stem cells undergo a diverse program of biological changes upon ex vivo cultivation that include numerical and structural chromosomal abnormalities, point mutations, variation of telomere length, and epigenetic instability. As the field moves forward, the growing awareness of the risk factors… Expand
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