Concise Review: Genomic Instability in Human Stem Cells: Current Status and Future Challenges

  title={Concise Review: Genomic Instability in Human Stem Cells: Current Status and Future Challenges},
  author={Pedro H. Oliveira and Cl{\'a}udia Lobato da Silva and Joaquim M S Cabral},
  journal={STEM CELLS},
Genomic instability is recognized as one of the most important hurdles in the expanding field of stem cell‐based therapies. In the recent years, an accumulating body of evidence has shown that human stem cells undergo a diverse program of biological changes upon ex vivo cultivation that include numerical and structural chromosomal abnormalities, point mutations, variation of telomere length, and epigenetic instability. As the field moves forward, the growing awareness of the risk factors… 

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Cell Therapy With Human ESC-Derived Cardiac Cells: Clinical Perspectives

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Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy

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Virtual karyotyping of pluripotent stem cells on the basis of their global gene expression profiles

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Genomic alterations in cultured human embryonic stem cells

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Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells.

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