Concise Review: Cardiac Disease Modeling Using Induced Pluripotent Stem Cells.

@article{Yang2015ConciseRC,
  title={Concise Review: Cardiac Disease Modeling Using Induced Pluripotent Stem Cells.},
  author={Chunbo Yang and Jumana Yousef Al-Aama and Miodrag Stojkovi{\'c} and Bernard D Keavney and Andrew W. Trafford and Majlinda Lako and Lyle Armstrong},
  journal={Stem cells},
  year={2015},
  volume={33 9},
  pages={2643-51}
}
Genetic cardiac diseases are major causes of morbidity and mortality. Although animal models have been created to provide some useful insights into the pathogenesis of genetic cardiac diseases, the significant species differences and the lack of genetic information for complex genetic diseases markedly attenuate the application values of such data. Generation of induced pluripotent stem cells (iPSCs) from patient-specific specimens and subsequent derivation of cardiomyocytes offer novel avenues… CONTINUE READING