Concerted activation of two potential proto-oncogenes in carcinomas induced by mouse mammary tumour virus

@article{Peters1986ConcertedAO,
  title={Concerted activation of two potential proto-oncogenes in carcinomas induced by mouse mammary tumour virus},
  author={Gordon G Peters and Audrey E. Lee and Clive Dickson},
  journal={Nature},
  year={1986},
  volume={320},
  pages={628-631}
}
The induction of tumours by retroviruses lacking transduced oncogenes can involve the transcriptional or functional activation of cellular proto-oncogenes by an integrated provirus1–8. Thus, the two cellular genes int-1 and int-2, identified as common targets for activation by mouse mammary tumour virus (MMTV), may constitute previously unrecognized oncogenes9,10. In tumours, proviral insertion at these loci leads to expression of messenger RNAs which are undetectable in normal mammary glands11… CONTINUE READING

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