Concerted actions of renal endothelial and macula densa NO systems in the maintenance of extracellular fluid volume.

It is now clear that nitric oxide (NO) exerts a substantial influence on renal function and that the kidney has a high capacity to produce NO. However, there are at least two different NO systems in the kidney. The interplay between NO generated by the endothelium and by the macula densa is considered in this review. It seems that endothelial NO increases… CONTINUE READING