Concerted action of two cation filters in the aquaporin water channel.

  title={Concerted action of two cation filters in the aquaporin water channel.},
  author={Binghua Wu and Christina Steinbronn and Magnus Alsterfjord and Thomas Zeuthen and Eric Beitz},
  journal={The EMBO journal},
  volume={28 15},
Aquaporin (AQP) facilitated water transport is common to virtually all cell membranes and is marked by almost perfect specificity and high flux rates. Simultaneously, protons and cations are strictly excluded to maintain ionic transmembrane gradients. Yet, the AQP cation filters have not been identified experimentally. We report that three point mutations turned the water-specific AQP1 into a proton/alkali cation channel with reduced water permeability and the permeability sequence: H(+) >>K… CONTINUE READING
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