Concerted action of the PHD, chromo and motor domains regulates the human chromatin remodelling ATPase CHD4

@inproceedings{Morra2012ConcertedAO,
  title={Concerted action of the PHD, chromo and motor domains regulates the human chromatin remodelling ATPase CHD4},
  author={Rosa Morra and Benjamin M. Lee and Heather M. Shaw and Roman Tuma and Erika J. Mancini},
  booktitle={FEBS letters},
  year={2012}
}
  • Rosa Morra, Benjamin M. Lee, +2 authors Erika J. Mancini
  • Published in FEBS letters 2012
  • Medicine, Biology
  • CHD4, the core subunit of the Nucleosome Remodelling and Deacetylase (NuRD) complex, is a chromatin remodelling ATPase that, in addition to a helicase domain, harbors tandem plant homeo finger and chromo domains. By using a panel of domain constructs we dissect their roles and demonstrate that DNA binding, histone binding and ATPase activities are allosterically regulated. Molecular shape reconstruction from small-angle X-ray scattering reveals extensive domain-domain interactions, which… CONTINUE READING

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