Concerted action of the PHD, chromo and motor domains regulates the human chromatin remodelling ATPase CHD4

@article{Morra2012ConcertedAO,
  title={Concerted action of the PHD, chromo and motor domains regulates the human chromatin remodelling ATPase CHD4},
  author={R. Morra and B. M. Lee and H. Shaw and R. Tuma and E. Mancini},
  journal={Febs Letters},
  year={2012},
  volume={586},
  pages={2513 - 2521}
}
CHD4, the core subunit of the Nucleosome Remodelling and Deacetylase (NuRD) complex, is a chromatin remodelling ATPase that, in addition to a helicase domain, harbors tandem plant homeo finger and chromo domains. By using a panel of domain constructs we dissect their roles and demonstrate that DNA binding, histone binding and ATPase activities are allosterically regulated. Molecular shape reconstruction from small‐angle X‐ray scattering reveals extensive domain‐domain interactions, which… Expand
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